Molecular Electrostatic Potentials

Every molecule has a unique electrostatic surface potential. This potential is critically important for how a molecule interacts with proteins and other biological agents. Electron and charge transfer is central to many biological processes and is a direct result of interacting surface potentials. 

Artificial magnetic fields are capable of triggering a similar receptor response and conformational change in the absence of a physical drug or molecular agonist. The energy spectrum of these fields has been termed ulRFE® and this technology has also been shown to selectively knock down protein pathways for therapeutic purposes.

For a full overview of how magnetic fields have been shown to cause an effect on biological systems, see the technical white paper from our partner company.

 

HAPBEE'S DELIVERY DEVICE

Hapbee leverages ulRFE® delivery technology licensed and adapted from EMulate Therapeutics to bring the first commercially available device in this pioneering approach to magnetic stimulation. The Hapbee device uses specific and precise oscillating magnetic fields with the proper vector and duration to confer a charge along an electron pathway to cause a discrete bioactive response, unique to each of our signals. 

Hapbee is licensed and adapted from Emulate Therapeutics and supported by a family of 32 patents. Hapbee harnesses the power of these surface potentials and broadcasts them in a small volume around the device to help users experience a desired state of mind such as sleepiness, relaxation, attention, and focus.

HAPBEE SIGNAL ACQUISITION

Hapbee’s signals come from analytically measuring the electrostatic surface potential of solvated molecules using some of the world's most sensitive magnetometers, acquisition pathways, and advanced signal processing. The electrostatic surface potential of a molecule is of critical importance to the binding affinity of a molecule, and a substance’s bioactivity. This electrostatic surface potential is in constant motion and is driven by the nonrandom internal dynamics of the molecular system. As surface charge moves, a small magnetic flux field is generated. The electrostatic surface potential of a molecule can be indirectly measured and recorded as an oscillating magnetic field using a SQUID magnetometer. Hapbee uses a specialized liquid Helium cooled, superconducting, ‘SQUID’ magnetometer to sense and record “real-time” changes in the magnetic environment (10 -15 Tesla) surrounding a molecular target in a solution. Temporal data, representing changes in the magnetic environment, are measured, stored and processed. They can be used later to reconstruct the original magnetic flux environment when played back through the Hapbee wearable device.

 

OTHER ulRFE® APPLICATIONS

Hapbee is building the commercial face of ulRFE® and Hapbee is not a medical device. Another form of ulRFE is being advanced by EMulate Therapeutics and is in clinical trials as a treatment for brain cancer with promising results. A summary of these results and studies from one of the world's foremost neurooncologists, Dr. Victor Levin.